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Practical Information
Domestic flights (mainly Air Panama) connect Panama City with Bocas del Toro and David quickly -- often the practical choice given how mountainous the country's road network can be.
The Pan-American Highway makes driving between Panama City, the Azuero Peninsula, and Chiriquí straightforward, though it stops entirely at the Darién Gap.
Within Panama City, the Metro (Central America's first subway system) and buses cover the city well, and rideshare apps are widely available.
Panama is one of the more stable and safer countries in Central America to visit, with most visitors experiencing nothing beyond routine city precautions -- though, as with any country, risk varies significantly by neighborhood and region.