The Grenfell House Museum is located in Newfoundland, Canada and is the restored house of Sir Wilfred Thomason Grenfell. Sir Wilfred was a medical missionary and the house was designed by him and his fiancée, Anne Elizabeth Mac Clanahan. The house was built in 1910. The house was turned into a Registered Heritage Structure in 1986 by the Heritage Foundation of Newfoundland and Labrador.

The museum is a part of the Grenfell Historic Properties and is operated by the Grenfell Historical Society. It honours the philanthropic and social works of Sir Wilfred. He had built many schools, orphanages, and hospitals in Newfoundland and Labrador.

The museum has two floors and both these are filled with exhibits showing the history of the Grenfell. There also is a short video as part of the exhibition. The museum also has the Grenfell cloth, which is a versatile fabric, made of Egyptian cotton. This fabric was invented in 1922 and can withstand the coldest of winters. Visitors can buy dresses made of Grenfell cloth from the Grenfell Handicrafts.

There is an entry fee to the Grenfell museum and the prices vary for individuals, families, adults, children, and senior citizens. It will take around an hour to tour around the museum completely.