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Italy
Practical Information
Trains are the backbone of getting around Italy, and usually the best option between major cities. High-speed Frecciarossa and Italo services connect Milan, Venice, Florence, Rome, and Naples in a few hours each, while the regional network -- slower, cheaper, no reservation needed -- reaches almost everywhere else.
A car is genuinely useful, sometimes necessary, for rural regions like Tuscany's countryside, Puglia, or Sicily's interior, where train service thins out. It's a liability in historic city centers, though: most have a ZTL ("Zona a Traffico Limitato") restricting non-resident vehicles, enforced by camera and finable even for a rental car days after the trip ends.
Domestic flights connect the mainland to Sicily and Sardinia quickly, though the train-plus-ferry route is common too. Within cities, walking covers most historic centers on its own -- many, including central Venice and much of Florence, are largely car-free by design.
Italy is a safe country to visit by most measures -- violent crime against travelers is rare. The practical risks visitors actually run into are almost entirely petty and preventable.