The South Carolina Confederate Relic Room and Military Museum, also called the Confederate Military Museum, was established in 1896. Considered as the third oldest museum in South Carolina, it serves as the repository of the state's military artifacts from the colonial era to present times.

The South Carolina Confederate Relic Room and Military Museum was previously located at the South Carolina State House, but was transferred to the War Memorial Building near the University of South Carolina during the middle of the 20th century. In 2002, the museum was moved once again to the Columbia Mills Building. In 2007, the museum was renovated to feature a new gallery.

The South Carolina Confederate Relic Room and Military Museum is home to different artifacts. Visitors can view relics and souvenirs from the Civil War, Mexican War, Revolutionary War, Spanish-American War, World War I, World War II, and even Bush's war against terror. Archive materials such as the documents from Colin J. McRae, a confederate officer, and artifacts from South Carolinians who fought the Spanish-American war are viewable by appointment.

The museum is also home to the entries from the "Write from the Front Program." The aforementioned program is a collection of photographs, mails, and artifacts that South Carolina residents who serve the military front have obtained.