Numerous architects worked on the Renaissance-style building in the 16th century, including Bartolomeo Bon and his son Petro, as well as Sante Lombardo, Antonio Scarpagnino and Giangiacomo dei Grigi,
In 1564, soon after the scuola’s completion, the artist Tintoretto was commissioned to paint a central panel on the ceiling of the Sala dell’Albergo. He later adorned the walls and ceilings of both the Salla dell’Albergo and the Sala Superiore with a complete cycle of paintings, considered by many to be his greatest masterpiece.